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Prof. William H. Seiple (Invited faculty – Lighthouse Inc.)Vision Institute
Aging in Vision and Action Lab
CNRS – INSERM – University Pierre&Marie Curie 17, rue Moreau F-75012 Paris, France Lighthouse International
Arlene R. Gordon Research Institute
111 E 59th St, New York NY 10022-1202
Phone: +1 (800) 284-4422
email:
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William Seiple is the Director of the Arlene R Gordon Research Institute and Vice President of Research at Lighthouse-Guild. He also holds Professorships of Ophthalmology at NY Univ. School of Medicine, at the State Univ. of NY Optometry School, and at the Univ. of Illinois Medical Center. He has also been an invited Prof. of Neuroscience at UPMC. He has extensive experience in the clinical and basic science aspects of eye disease. He is an expert in visual electrophysiology, psychophysics, and low-vision. He focuses on the functional consequences of disorders of the visual system, with the aims of improving adaptation to vision loss. He is passionate about leveraging his knowledge to the development of evidence-based rehabilitation methods.
CV and Publication List (pdf): [ download ]
Publications
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Show All - Journals - Peer-reviewed conference proceedings - Others
2019
- Healthy and pathological visual aging in a French follow-up cohort study. Investigative Ophthalmology & Visual Science - ARVO, 60:5915. (2019)
2018
- Performance of real-world functional tasks using the BrainPort Vision Pro in persons blinded by traumatic injury. Optometry and Vision Science, In Press. (2018)
- Comparative effectiveness of a self-guided eye movement reading training program: clinic vs. home. (2018)
- The effects of lighting on reading speed as a function of text size. American Journal of Occupational Therapy, 73:7202345020p1-7202345020p7. (2018)
- Test re-test variability of the LuxIQ lighting assessment. Optometry and Vision Science, In Press. (2018)
- Does the extended stimulus luminance range of the MAIA microperimeter have clinical value?. Optometry and Vision Science, In Press. (2018)
- Current practice in low vision rehabilitation of age-related macular degeneration and usefulness of virtual reality as a rehabilitation tool. Journal of Aging Science, 6(2):194. (2018)
2017
- Do individuals with Stargardt’s macular dystrophy fixate eccentrically when asked to look straight ahead?. Ophthalmology Retina, 1:524-530. (2017)
2016
- The functional performance of the BrainPort V100® device in persons who are profoundly blind. The Journal of Visual Impairments & Blindness, March-April:77-88. (2016)
- Ophthalmologic baseline characteristics and 2-year ophthalmologic safety profile of Pramipexole IR versus Ropinirole IR in patients with early Parkinson’s disease. Parkinson Disease, 2016:1-14. (2016)
- Test re-test reliability of luminance and color temperature preferences in normally sighted and low vision patients using the LuxIQ. (2016)
2013
- Abnormal fixation in individuals with age-related macular degeneration when viewing an image of a face. Optometry and Vision Science, 90(1):45-56. (2013)
2012
- Microperimetry: a review of fundus related perimetry. Optometry Reports, 2012:E2. (2012)
- Microperimetry in Rehabilitation. In Jackson M, Crossland MC, Mastropasqua L, Midema E, Vingolo EM, editors, Handbook of Microperimetry, Nidek Technologies, Padova, Italy. (2012)
- The physics and psychophysics of microperimetry. Optometry and Vision Science, 89(8):1182-91. (2012)
2011
- Effect of depression on actual and perceived effects of reading rehabilitation for people with central vision loss. Journal of Rehabilitation Research & Development, 48(9):1101-8. (2011)
- Inner segment-outer segment junctional layer integrity and corresponding retinal sensitivity in dry and wet forms of age-related macular degeneration. Retina, 31(2):364-70. (2011)
- Reading rehabilitation of individuals with AMD: relative effectiveness of training approaches. Investigative Ophthalmology & Visual Science, 52(6):2938-44. (2011)
- Clinical value, normative retinal sensitivity values, and intrasession repeatability using a combined spectral domain optical coherence tomography/scanning laser ophthalmoscope microperimeter. Eye, 25(2):245-51. (2011)
2010
- Combined three-dimensional spectral OCT/SLO topography and Microperimetry: steps toward achieving functional spectral OCT/SLO. Ophthalmic Research, 43(2):92-8. (2010)
- A comparison between microperimetry and standard achromatic perimetry of the central visual field in eyes with glaucomatous paracentral visual-field defects. British Journal of Ophthalmology, 94(1):64-7. (2010)
2008
- Preferred retinal locus in macular disease: characteristics and clinical implications. Retina, 28(9):1234-40. (2008)
- Macular structure and vision of patients with macular heterotopia secondary to retinopathy of prematurity. Retina, 28(8):1111-6. (2008)
- Detection of mosaic retinal dysfunction in choroideremia carriers electroretinographic and psychophysical testing. Ophthalmology, 115(4):723-9. (2008)
2007
- Scotopic sensitivity and color vision with a blue-light-absorbing intraocular lens. Journal of Cataract & Refractive Surgery, 33(4):667-72. (2007)
- Eccentricity-dependent changes in local onset and offset responses in patients with progressive cone dystrophy. Vision Research, 47(17):2297-304. (2007)
- Retinal dysfunction in carriers of bardet-biedl syndrome. Ophthalmic Genetics, 28(3):163-8. (2007)
- Multifocal ERG findings in carriers of X-linked retinoschisis. Documenta Ophthalmologica, 114(1):21-6. (2007)
2006
- Perifoveal function in patients with North Carolina macular dystrophy: the importance of accounting for fixation locus. Investigative Ophthalmology & Visual Science, 47(4):1703-9. (2006)
2005
- The multifocal visual evoked potential: an objective measure of visual fields?. Vision Research, 45(9):1155-63. (2005)
- Eye-movement training for reading in patients with age-related macular degeneration. Investigative Ophthalmology & Visual Science, 46(8):2886-96. (2005)
- Driving performance of glaucoma patients correlates with peripheral visual field loss. Journal of Glaucoma, 14(2):145-50. (2005)
- Comprehensive functional vision assessment of patients with North Carolina macular dystrophy (MCDR1). Retina, 25(4):489-97. (2005)
- Use of prisms for navigation and driving in hemianopic patients. Ophthalmic & Physiological Optics, 25(2):128-35. (2005)
- Assessing responses of the macula in patients with macular holes using a new system measuring localized visual acuity and the mfERG. Documenta Ophthalmologica, 110(2-3):181-91. (2005)
- Contrast response properties of magnocellular and parvocellular pathways in retinitis pigmentosa assessed by the visual evoked potential. Investigative Ophthalmology & Visual Science, 46(8):2967-73. (2005)
2004
- Atypical multifocal ERG responses in patients with diseases affecting the photoreceptors. Vision Research, 44(25):2867-74. (2004)
- Rod and cone photoreceptor function in patients with cone dystrophy. Investigative Ophthalmology & Visual Science, 45(1):275-81. (2004)
- Test-retest reliability of the multifocal electroretinogram and humphrey visual fields in patients with retinitis pigmentosa. Documenta Ophthalmologica, 109(3):255-72. (2004)
- Multidimensional visual field maps: relationships among local psychophysical and local electrophysiological measures. Journal of Rehabilitation Research & Development, 41(3A):359-72. (2004)
- Relationship of retinal structural and clinical vision parameters to driving performance of diabetic retinopathy patients. Journal of Rehabilitation Research & Development, 41(3A):347-58. (2004)
2003
- The effect of variably tinted spectacle lenses on visual performance in cataract subjects. Eye & Contact Lens: Science & Clinical Practice, 29(1):17-20. (2003)
- Multifocal electroretinography as a function of age: the importance of normative values for older adults. Investigative Ophthalmology & Visual Science, 44(4):1783-92. (2003)
2002
- Local cone and rod system function in progressive cone dystrophy. Investigative Ophthalmology & Visual Science, 43(7):2364-73. (2002)
- Effect of variable tinted spectacle lenses on visual performance in control subjects. CLAO Journal, 28(2):80-2. (2002)
- The spatial distribution of selective attention assessed using the multifocal visual evoked potential. Vision Research, 42(12):1513-21. (2002)
- A method for comparing psychophysical and multifocal electroretinographic increment thresholds. Vision Research, 42(2):257-69. (2002)
- Detection using the multifocal electroretinogram of mosaic retinal dysfunction in carriers of X-linked retinitis pigmentosa. Ophthalmology, 109(3):560-8. (2002)
- Localized retinal dysfunction in central serous chorioretinopathy as measured using the multifocal electroretinogram. Ophthalmology, 109(7):1243-50. (2002)
2001
- Retinal pigment epithelial dysfunction in patients with pigment dispersion syndrome: implications for the theory of pathogenesis. Archives of Ophthalmology, 119(9):1291-5. (2001)
- Local cone and rod system function in patients with retinitis pigmentosa. Investigative Ophthalmology & Visual Science, 42(3):779-88. (2001)
- Variable tinted spectacle lenses: a comparison of aesthetics and visual preference. CLAO Journal, 27(3):121-4. (2001)
- Duration thresholds for target detection and identification in the peripheral visual field. Optometry and Vision Science, 78(3):169-76. (2001)
- Lateral spread of adaptation as measured with the multifocal electroretinogram. Visual Neuroscience, 18(5):687-94. (2001)
- Perceived and actual performance of daily tasks: relationship to visual function tests in individuals with retinitis pigmentosa. Ophthalmology, 108(1):65-75. (2001)
2000
- Retinal function in diabetic macular edema after focal laser photocoagulation. Investigative Ophthalmology & Visual Science, 41(11):3655-64. (2000)
- The nature and extent of retinal dysfunction associated with diabetic macular edema. Investigative Ophthalmology & Visual Science, 41(11):3643-54. (2000)
- Electrophysiologic assessment of photoreceptor function in patients with primary open-angle glaucoma. Journal of Glaucoma, 9(2):163-8. (2000)
- A curriculum for training patients with peripheral visual field loss to use bioptic amorphic lenses. Journal of Rehabilitation Research & Development, 37(5):607-19. (2000)
- Measuring the effectiveness of bioptic telescopes for persons with central vision loss. Journal of Rehabilitation Research & Development, 37(1):101-8. (2000)
1999
- Identifying inner retinal contributions to the human multifocal ERG. Vision Research, 39(13):2285-91. (1999)
1998
- Assessment of local retinal function in patients with retinitis pigmentosa using the multi-focal ERG technique. Vision Research, 38(1):163-79. (1998)
- Multifocal rod electroretinograms. Investigative Ophthalmology & Visual Science, 39(7):1152-62. (1998)
- Use of bioptic amorphic lenses to expand the visual field in patients with peripheral loss. Optometry and Vision Science, 75(7):518-24. (1998)
1997
- Evidence for photoreceptor changes in patients with diabetic retinopathy. Investigative Ophthalmology & Visual Science, 38(11):2355-65. (1997)
- Relative effects of aging and age-related macular degeneration on peripheral visual function. Optometry and Vision Science, 74(3):152-9. (1997)
- A comparison of the components of the multifocal and full-field ERGs. Visual Neuroscience, 14(3):533-44. (1997)
- Electroretinographic and psychophysical findings during early and late stages of human immunodeficiency virus infection and cytomegalovirus retinitis. Ophthalmology, 104(3):445-53. (1997)
1996
- Rod phototransduction in transgenic mice expressing a mutant opsin gene. Journal of the Optical Society of America, A, Optics, Image Science, & Vision, 13(3):577-85. (1996)
- Rates of change differ among measures of visual function in patients with retinitis pigmentosa. Ophthalmology, 103(3):398-405. (1996)
- Outer-retina locus of increased flicker sensitivity of the peripheral retina. Journal of the Optical Society of America, A, Optics, Image Science, & Vision, 13(3):658-66. (1996)
- Age-related functional field losses are not eccentricity dependent. Vision Research, 36(12):1859-66. (1996)
1995
- The effects of random element loss on letter identification: implications for visual acuity loss in patients with retinitis pigmentosa. Vision Research, 35(14):2057-66. (1995)
- Comparison of visual evoked potential and psychophysical contrast sensitivity. International Journal of Neuroscience, 80(1-4):173-80. (1995)
- Relative effects of age and compromised vision on driving performance. Human Factors, 37(2):430-6. (1995)
- Symmetry discrimination in patients with retinitis pigmentosa. Vision Research, 35(11):1633-40. (1995)
1994
- The effects of dopamine blockade on the human flash electroretinogram. Documenta Ophthalmologica, 86(1):1-10. (1994)
- The 'OFF' response of the human electroretinogram does not contribute to the brief flash 'b-wave'. Visual Neuroscience, 11(4):667-73. (1994)
- Visual evoked potentials following abrupt contrast changes. Vision Research, 34(21):2813-21. (1994)
1993
- The effects of acetazolamide on visual function in retinitis pigmentosa. Investigative Ophthalmology & Visual Science, 34(1):269-73. (1993)
- Electro-oculogram changes in patients with ocular hypertension and primary open-angle glaucoma. Documenta Ophthalmologica, 83(2):103-10. (1993)
- Comparison of P100 and P300 cortical potentials in spatial frequency discrimination. Documenta Ophthalmologica, 85(2):173-83. (1993)
- Sites of cone system sensitivity loss in retinitis pigmentosa. Investigative Ophthalmology & Visual Science, 34(9):2638-45. (1993)
- Effects of age and hemianopic visual field loss on driving. Optometry and Vision Science, 70(12):1031-7. (1993)
1992
- A comparison of photopic and scotopic electroretinographic changes in early diabetic retinopathy. Investigative Ophthalmology & Visual Science, 33(10):2773-80. (1992)
- Maculopathy caused by intra-arterially administered cisplatin and intravenously administered carmustine. American Journal of Ophthalmology, 113(4):435-8. (1992)
- Human VEP contrast modulation sensitivity: separation of magno- and parvocellular components. Electroencephalography & Clinical Neurophysiology, 84(1):1-12. (1992)
- Temporal frequency dependent adaptation at the level of the outer retina in humans. Vision Research, 32(11):2043-8. (1992)
1990
- Electrophysiological and psychophysical flicker sensitivity in patients with primary open-angle glaucoma and ocular hypertension. Investigative Ophthalmology & Visual Science, 31(9):1863-8. (1990)
1989
- Losses of temporal modulation sensitivity in retinal degenerations. British Journal of Ophthalmology, 73(6):440-7. (1989)
- An examination of VEP response phase. Electroencephalography & Clinical Neurophysiology, 73(6):520-31. (1989)
- The clinical utility of visual-evoked potential acuity testing. American Journal of Ophthalmology, 108(5):572-7. (1989)
1988
- Variability of the pattern electroretinogram. Documenta Ophthalmologica, 70(1):103-15. (1988)
- Changes in the focal electroretinogram with retinal eccentricity. Documenta Ophthalmologica, 70(1):29-36. (1988)
1987
- Contrast sensitivity of the human pattern electroretinogram. Investigative Ophthalmology & Visual Science, 28(1):151-7. (1987)
- Rod influence on thresholds using different detection criteria during dark adaptation. Acta Psychologica, 64(3):261-70. (1987)
- Cone function in congenital nyctalopia. Documenta Ophthalmologica, 65(3):307-18. (1987)
- Pattern electroretinogram threshold does not show contrast adaptation. Investigative Ophthalmology & Visual Science, 28(9):1614-6. (1987)
1986
- Electrophysiological assessment of aphakic cystoid macular oedema. British Journal of Ophthalmology, 70(11):819-24. (1986)
- Evaluating macular function using the focal ERG. Investigative Ophthalmology & Visual Science, 27(7):1123-30. (1986)
- Objective assessment of temporal modulation transfer functions using the focal ERG. American Journal of Optometry & Physiological Optics, 63(1):1-6. (1986)
1984
- Electrophysiological confirmation of orientation-specific contrast losses in multiple sclerosis. Annals of the New York Academy of Sciences, 436:487-91. (1984)
- Contrast sensitivity loss in multiple sclerosis. Selectivity by eye, orientation, and spatial frequency measured with the evoked potential. Investigative Ophthalmology & Visual Science, 25(6):632-9. (1984)
- Spatiotemporal conditions which elicit or abolish the oblique effect in man: direct measurement with swept evoked potential. Vision Research, 24(6):579-86. (1984)
- Lock-in techniques for the swept stimulus evoked potential. Journal of Clinical Neurophysiology, 1(4):409-36. (1984)
- A rapid evoked potential index of cortical adaptation. Electroencephalography & Clinical Neurophysiology, 59(6):454-64. (1984)
- The assessment of evoked potential contrast thresholds using real-time retrieval. Investigative Ophthalmology & Visual Science, 25(6):627-31. (1984)
1983
- The 20/20 eye in multiple sclerosis. Neurology, 33(8):1015-20. (1983)
- The pattern electroretinogram in optic nerve disease. Ophthalmology, 90(9):1127-32. (1983)
- Recording the pattern electroretinogram: a cautionary note. Investigative Ophthalmology & Visual Science, 24(6):796-8. (1983)
1974
- Binocular summation and suppression: visually evoked cortical responses to dichoptically presented patterns of different spatial frequencies. Vision Research, 14(11):1169-80. (1974)
1973
- Binocular summation of visually evoked responses to pattern stimuli in humans. Vision Research, 13(8):1433-46. (1973)
1972
- Evoked cortical responses to dichoptically presented patterned light flashes: interocular interaction. T.I.T. Journal of Life Sciences, 2(1):27-33. (1972)