Jimmy Murari (PhD student Sorbonne University)
Aging in Vision and Action Lab
CNRS – INSERM – Sorbonne University
17, rue Moreau F-75012 Paris, France
Phone: +33 (0)1 53 46 26 69
Age-related Macular Degeneration (AMD) is the cause of irreversible visual loss of over 190 million people in 2020 with a projection of 288 million cases in 2040. One of the main challenges in studying AMD is to be able to detect it at the earliest possible stage. According to the literature, there seem to be some changes in the eye micro-movements during fixation when developing AMD. The goal of my Ph.D. project is to highlight those subtle kinematic changes and correlate them to the patient’s retinal structural change, disease progression, and functional deterioration of the vision. This experimental and clinical neuroscience work linking psychophysics tests and eye imaging should lead to a biomarker for AMD and the presence of drusen at a pre-clinical stage.
I am also part of the Paris Eye Imaging team at the Quinze-Vingts Hospital, a group of ophthalmologists and physicists studying high-resolution imaging of the human eye. There, I work at the Clinical Investigation Center (CIC) where I perform psychophysics tests during the acquisition of high-resolution high-speed videos of the retina, in order to study eye micro-movements at a precision never seen before.
I hold a physics and photonics engineering degree from the Institut d’Optique Graduate School in Paris-Saclay. After my engineering school, an interest towards Biomedical sciences and imaging methods grew in me and led me to a MSc in Biomedical Engineering at Imperial College London, in the Medical Physics Stream. There, I developed my knowledge in life sciences, and I learned how to link my skills in photonics to the biomedical field. My master’s research project focused on Expansion Microscopy (ExM) applied on tissues, at the Vermot Lab of Imperial College. ExM is a recent imaging method which aims at physically expanding samples which allows the study of structures normally smaller than the diffraction limit. After that lab experience, I was convinced I wanted to pursue a PhD and I joined the Aging in Vision and Action lab at the Vision Institute in October 2021.
Keywords: eye movements, AMD, imaging, eye tracking, fixation